Beams Document 3304-v2

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A Novel Tele-Manipulation for Cell Injection

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Camille M. Ginsburg
Updated by:
Camille M. Ginsburg
Document Created:
13 Feb 2009, 10:40
Contents Revised:
19 Mar 2010, 12:13
Metadata Revised:
19 Mar 2010, 12:13
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19 Mar 2010, 14:30
Currently, cell manipulations for Intra Cyto Plasmatic Cell Injection (ICSI) are performed manually. These highly precise operations require high-skilled professional operators. However, the success and survival rate of the cells is very low due to the great sensitivity of cells. Moreover, while manipulating, the operator cannot feel any interaction with the cells because of their negligible mass. Conventional cell manipulation does not have the ability to provide force feedback to an operator. Therefore all the operations are based on the visual information provided by the high-precision microscope. In addition, vibrations of human’s hand can affect the quality of micromanipuation tasks. Therefore, there exists a need to design a robotic arm for cell injection process and to incorporate haptic force feedback along with visual feedback into a cell injection system, with the capability of representing contact forces in the range of µN-mN. In order to know the contact forces experiencing by the cell membrane, a good understanding of the biological cell dynamics throughout the cell injection process is necessary.
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